Early stages in the biogenesis of eukaryotic β‐barrel proteins. Issue 17 (2nd July 2017)

• Record Type: Journal Article
• Authors: Jores, Tobias; Rapaport, Doron
• Other Names: Just Wilhelm guestEditor.
• Is Part Of: FEBS letters. Volume 591:Issue 17(2017)
• Page Start: 2671
• Page End: 2681
• Publication Date: 2017-07-02
• Subjects: chloroplasts -- mitochondria -- β‐barrel proteins; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.12726
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : The endosymbiotic organelles mitochondria and chloroplasts harbour, similarly to their prokaryotic progenitors, β‐barrel proteins in their outer membrane. These proteins are encoded on nuclear DNA, translated on cytosolic ribosomes and imported into their target organelles by a dedicated machinery. Recent studies have provided insights into the import into the organelles and the membrane insertion of these proteins. Although the cytosolic stages of their biogenesis are less well defined, it is speculated that upon their synthesis, chaperones prevent β‐barrel proteins from aggregation and keep them in an import‐competent conformation. In this Review, we summarize the current knowledge about the biogenesis of β‐barrel proteins, focusing on the early stages from the translation on cytosolic ribosomes to the recognition on the surface of the organelle. Abstract :