Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes. Issue 9 (28th July 2017)

• Record Type: Journal Article
• Authors: van Coevorden‐Hameete, Marleen H.; van Beuningen, Sam F.B.; Perrenoud, Matthieu; Will, Lena M.; Hulsenboom, Esther; Demonet, Jean‐Francois; Sabater, Lidia; Kros, Johan M.; Verschuuren, Jan J.G.M.; Titulaer, Maarten J.; de Graaff, Esther; Sillevis Smitt, Peter A.E.; Hoogenraad, Casper C.
• Is Part Of: Annals of clinical and translational neurology. Volume 4:Issue 9(2017)
• Page Start: 680
• Page End: 686
• Publication Date: 2017-07-28
• Subjects: Nervous system -- Diseases -- Periodicals; Neurology -- Periodicals; 616.8005
• DOI: 10.1002/acn3.396
• Languages: English
• ISSNs: 2328-9503

Abstract

Abstract: Paraneoplastic neurological syndromes (PNS) are often characterized by the presence of antineuronal antibodies in patient serum or cerebrospinal fluid. The detection of antineuronal antibodies has proven to be a useful tool in PNS diagnosis and the search for an underlying tumor. Here, we describe three patients with autoantibodies to several epitopes of the axon initial segment protein tripartite motif 46 (TRIM46). We show that anti‐TRIM46 antibodies are easy to detect in routine immunohistochemistry screening and can be confirmed by western blotting and cell‐based assay. Anti‐TRIM46 antibodies can occur in patients with diverse neurological syndromes and are associated with small‐cell lung carcinoma.