IgG4-related disease manifesting as pericarditis with elevated adenosine deaminase and IL-10 levels in pericardial fluid. Issue 5 (3rd September 2017)

• Record Type: Journal Article
• Authors: Sendo, Sho; Saegusa, Jun; Morinaga, Yukiko; Kawakami, Fumi; Kogata, Yoshinori; Kageyama, Goichi; Morinobu, Akio
• Is Part Of: Modern rheumatology. Volume 27:Issue 5(2017)
• Page Start: 894
• Page End: 897
• Publication Date: 2017-09-03
• Subjects: Adenosine deaminase -- IgG4-related disease -- IL-10 -- Pericarditis; Rheumatology -- Periodicals; 616.723005
• DOI: 10.3109/14397595.2015.1039628
• Languages: English
• ISSNs: 1439-7595

Abstract

Abstract : A 78-year-old female with massive pericardial effusion fulfilled diagnostic criteria for immunoglobulin G4 (IgG4)-related disease. Although her adenosine deaminase (ADA) level in the pericardial effusion was high, all the tests for tuberculosis infection were negative. Immunostaining of the pericardium biopsy specimen revealed remarkably increased IgG4-positive cells. This is the first report describing IgG4-related pericarditis with elevated ADA level. We also demonstrate the elevated interleukin-10 (IL-10) level in pericardial fluid and IL-10-producing T-cells in the pericardium.