Bone reconstruction in rat calvarial defects by chitosan/hydroxyapatite nanoparticles scaffold loaded with unrestricted somatic stem cells. (April 2015)

• Record Type: Journal Article
• Authors: Biazar, Esmaeil; Heidari Keshel, Saeed; Tavirani, Mostafa Rezaei; Jahandideh, Rahim
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 43:Number 2(2015:Apr.)
• Page Start: 112
• Page End: 116
• Publication Date: 2015-04
• Subjects: bone regeneration -- chitosan -- hydroxyapatite nanoparticles -- injectable scaffold -- unrestricted somatic stem cells; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2013.848874
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Calcium phosphates are one of the biomaterials that are used for bone regeneration. In this study, Hydroxyapatite (HAp) nanoparticles with chitosan gel filled with unrestricted somatic stem cells (USSCs) were used for healing calvarial bone in rat model. The healing effects of these injectable scaffolds with and without stem cells for bone regeneration were investigated by computed tomography (CT) analysis and pathology assays after 28 days of grafting. The results of CT analysis showing bone regeneration on the scaffolds, also the amounts of regenerated new bone for USSC scaffold was significantly greater than the scaffold without cell and untreated controls. Therefore, the combination of scaffold especially with USSC is considered as a useful method for bone regeneration.