Limited evidence for calcium supplementation in preeclampsia prevention: a meta-analysis and systematic review. (May 2015)

• Record Type: Journal Article
• Authors: Tang, Reuben; Tang, Ing Ching; Henry, Amanda; Welsh, Alec
• Is Part Of: Hypertension in pregnancy. Volume 34:Number 2(2015)
• Page Start: 181
• Page End: 203
• Publication Date: 2015-05
• Subjects: Preeclampsia -- Calcium -- Calcium supplementation -- Meta-analysis -- Systematic review; Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.3109/10641955.2014.988353
• Languages: English
• ISSNs: 1064-1955

Abstract

Abstract : Objective : This article synthesises evidence for calcium supplementation in preeclampsia prevention. Methods : Major databases and trial registries were searched, and comparisons were made against other meta-analyses. Results : Calcium supplementation reduced the overall risk of preeclampsia in 10 trials ( n = 24 787; risk ratio (RR) 0.62; 95% confidence interval [CI] 0.47–0.81). Its effect was larger in two subgroups: low-baseline calcium intake (RR 0.42 [0.23–0.76]) and increased risk of developing hypertensive disorders (RR 0.36 [0.10–0.98]). This effect was not significant amongst larger studies (RR 0.93 [0.83–1.04]). Funnel plotting suggested possible publication bias. Conclusion : Some evidence for calcium supplementation exists, but its utility is limited by the possibility of publication bias and a lack of large trials.