Synthesis, crystal structure, spectroscopy, thermal properties and carbonic anhydrase activities of new metal(II) complexes with mefenamic acid and picoline derivatives. Issue 16 (18th August 2017)

• Record Type: Journal Article
• Authors: Dilek, Esra; Caglar, Sema; Dogancay, Nesrin; Caglar, Bulent; Sahin, Onur; Tabak, Ahmet
• Is Part Of: Journal of coordination chemistry. Volume 70:Issue 16(2017)
• Page Start: 2833
• Page End: 2852
• Publication Date: 2017-08-18
• Subjects: Mefenamic acid -- picoline -- metal complex -- carbonic anhydrases; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2017.1366996
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: The mononuclear six metal(II) complexes ([Co(mef)2 (3-pic)2 (CH3 OH)2 ] (1 ), [Ni(mef)2 (3-pic)2 (CH3 OH)2 ] (2 ), [Cu(mef)2 (3-pic)2 ] (3 ), [Co(mef)2 (4-pic)2 ] (4 ), [Ni(mef)2 (4-pic)2 ] (5 ), and [Cu(mef)2 (4-pic)2 ] (6 ) with mefenamic acid and picoline ligands were synthesized, characterized, and their carbonic anhydrase inhibitory activities were evaluated. The six complexes were characterized by elemental analysis, FT-IR spectroscopy, and thermal analyses. The crystal structures of1, 3, and6 were determined by X-ray crystallography. The complexes have octahedral geometry. In1, the mefenamato ligand behaved as monodentate whereas in3 and6, the mefenamato ligand acted as a bidentate ligand. Complexes3 and6 consist of the mefenamate and 4-picoline ligands. In1, unlike the other complexes, methanol acted as a ligand and was involved in the coordination. Carbonic anhydrase I and II isoenzymes were purified from human erythrocytes. The in vitro effects of mefenamic acid, 3-picoline, 4-picoline, and the six metal(II) complexes on these isoenzymes were evaluated. Abstract :