Novel 1, 2, 3-triazolium-functionalized inulin derivatives: synthesis, free radical-scavenging activity, and antifungal activity. Issue 67 (31st August 2017)

• Record Type: Journal Article
• Authors: Li, Qing; Qiu, Lishushi; Tan, Wenqiang; Gu, Guodong; Guo, Zhanyong
• Is Part Of: RSC advances. Volume 7:Issue 67(2017)
• Page Start: 42225
• Page End: 42232
• Publication Date: 2017-08-31
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra08244d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A new class of inulin derivatives possessing 1, 2, 3-triazolium charged units by associating "click reaction" with efficient 1, 2, 3-triazole quaternization were designed and synthesized. The synthesized inulin derivatives possess excellent free radical-scavenging ability. Abstract : A new class of inulin derivatives possessing 1, 2, 3-triazolium charged units by associating "click reaction" with efficient 1, 2, 3-triazole quaternization were designed and synthesized. After the chemical modification, all the inulin derivatives showed good solubility in water, and exhibited excellent bioactivity compared to inulin. In the 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, the scavenging activity of 1, 2, 3-triazolium inulin derivatives (5a–5d ) (IC50 0.21–0.29 mg mL −1 ) was found to be higher than that of inulin derivatives (4a–4d ) (IC50 0.58–0.95 mg mL −1 ) and inulin.5a–5d (IC50 < 0.01 mg mL −1 ) also exhibited stronger inhibitory activity against superoxide anion formation than4a–4d (IC50 0.02–0.09 m g mL −1 ) and Vitamin C (IC50 0.02 mg mL −1 ). In the antifungal assays, 5a–5d also inhibited the growth of tested phytopathogens more effectively with inhibitory indices of 43.10–82.56% at 1.0 mg mL −1, compared with4a–4d and inulin. Based on these data, it is reasonable to propose that the introduction of 1, 2, 3-triazolium group through chemical modification is significant to enhance the free radical-scavenging activity and antifungal activity of inulin.