2, 4-Diamino-1, 3, 5-triazine-enabled Cu-catalyzed direct sulfonamidation of aromatic C–H bonds. Issue 34 (17th August 2017)

• Record Type: Journal Article
• Authors: Song, Chan; Wang, Tao; Yu, TingTing; Cui, Dong-Mei; Zhang, Chen
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 34(2017)
• Page Start: 7212
• Page End: 7217
• Publication Date: 2017-08-17
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob01872j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient copper acetate catalyzed sulfonamidation of arenes via C–H bond activation directed by a 2, 4-diamino-1, 3, 5-triazine chelating group under oxygen as a terminal oxidant has been developed. The reaction shows good regioselectivity and can be performed with a good yield at the gram scale. Abstract : An efficient copper acetate catalyzed sulfonamidation of arenes via C–H bond activation directed by a 2, 4-diamino-1, 3, 5-triazine chelating group under oxygen as a terminal oxidant has been developed. The reaction shows good regioselectivity and functional group tolerance, as well as providing a straightforward methodology for the preparation of ortho -monosulfonamidated arene derivatives in moderate to high yields. The sulfonamidation at the gram scale can be performed with a good yield.