Bioinspired Therapeutic Dendrimers as Efficient Peptide Drugs Based on Supramolecular Interactions for Tumor Inhibition1. Issue 14 (26th February 2015)

• Record Type: Journal Article
• Authors: Zhang, Xiao; Zhang, Zhijun; Xu, Xianghui; Li, Yunkun; Li, Yachao; Jian, Yeting; Gu, Zhongwei
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 14(2015)
• Page Start: 4289
• Page End: 4294
• Publication Date: 2015-02-26
• Subjects: antitumor agents -- dendrimers -- peptide drugs -- supramolecular chemistry -- tryptophan; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201500683
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Bioinspired tryptophan‐rich peptide dendrimers (TRPDs) are designed as a new type of dendritic peptide drugs for efficient tumor therapy. The TRPDs feature a precise molecular structure and excellent water solubility and are obtained in a facile process. Based on the unique features of peptide dendrimers, including highly branched structures, abundant terminal groups, and globular‐protein‐like architectures, the therapeutic dendrimers show significant supramolecular interactions with DNA through the tryptophan residues (indole rings and amino groups). Further experimental results indicate that TRPDs are efficient antitumor agents both in vitro and in vivo. Abstract : Tryptophan‐rich peptide dendrimers (TRPDs) with a precise molecular structure were developed as a new type of dendritic peptide drug for efficient tumor therapy. The significant supramolecular interactions between the therapeutic dendrimers and DNA were extensively studied, and experimental results indicate that TRPDs are efficient antitumor agents both in vitro and in vivo.