De novo hepatitis B virus infection after pediatric liver transplantations with hepatitis B core antibody‐positive donors: A single‐center 20‐yr experience. (4th February 2015)

• Record Type: Journal Article
• Authors: Lee, Yeoun Joo; Oh, Seak Hee; Kim, Kyung Mo; Song, Seung Min; Namgoong, Jung‐Man; Kim, Dae Yeon; Lee, Sung‐Gyu
• Is Part Of: Pediatric transplantation. Volume 19:Number 3(2015:May)
• Page Start: 267
• Page End: 272
• Publication Date: 2015-02-04
• Subjects: hepatitis B core antigen -- liver transplantation -- child -- Korea; Transplantation of organs, tissues, etc. in children -- Periodicals; 617.95408305
• DOI: 10.1111/petr.12432
• Languages: English
• ISSNs: 1397-3142

Abstract

Abstract: DNHB is common in countries with high prevalence of hepatitis B, and therefore, contracting hepatitis B after LT with HBcAb + grafts is a major concern. We studied DNHB in 247 children (aged <18 yr) who underwent LT from 1994 to 2013. Sixty‐six of 247 recipients received HBcAb + donor grafts. The incidence of DNHB was 5.7% (14 of 247 children) and that in HBcAb + donor grafts was 19.7% (13 of 66 children). The incidence of DNHB without LAM prophylaxis was 31.3% (nine of 29 children), while that with prophylaxis was 10.8% (four of 37 children). LAM prophylaxis negatively correlated with DNHB by Cox regression analysis (p = 0.028, odds ratio = 0.258). Among 13 DNHB patients with HBcAb + donor grafts, eight recovered from DNHB and four showed the emergence of LAM resistance. There was no DNHB‐related graft failure. This study showed that HBcAb + donor graft was associated with development of DNHB, and use of LAM prophylaxis decreased the incidence of DNHB with HBcAb + graft.