Hybrid polymeric nanoprobes for folate receptor-targeted photoacoustic imaging in vivo. (7th December 2016)

• Record Type: Journal Article
• Authors: Li, Yihong; Song, Yuanhui; Chen, Waner; Xu, Qien; Liu, Zhe
• Is Part Of: Materials chemistry frontiers. Volume 1:Number 5(2017)
• Page Start: 916
• Page End: 921
• Publication Date: 2016-12-07
• Subjects: Materials science -- Periodicals; Chemistry -- Periodicals; 540
• DOI: 10.1039/c6qm00227g
• Languages: English
• ISSNs: 2052-1529

Abstract

Abstract : Nanoprobes against cancer: to serve in the early detection and precise diagnosis of breast cancers in terms of nanomedicine, novel hybrid polymeric nanoprobes (PBCA-MB@CS-FA) were fabricated and applied to folate receptor-targeted photoacoustic (PA) imaging. Abstract : To construct biocompatible imaging nanoprobes and apply them to receptor-specific targeting of breast cancers is of great significance for precise diagnosis and personalized therapy serving nanomedicine. Herein, hybrid polymeric methylene blue-embedded nanoprobes (PBCA-MB@CS-FA) for folate receptor-targeted photoacoustic (PA) imaging have been successfully fabricated. Phantom imaging and in vitro cell experiments confirmed their apparent contrast enhancement and strong binding affinity. The administration into MDA-MB231 tumor-xenografted nude mice showed 10-fold higher intensity of PA signals compared to that of non-targeted control. These features make them promising PA nanoprobes for non-invasive molecular diagnosis, and more importantly for potential PA image-guided surgery/therapy against breast cancers in the early stage.