Bone Regeneration With a Collagen Model Polypeptides/α-Tricalcium Phosphate Sponge in a Canine Tibia Defect Model. Issue 2 (April 2015)

• Record Type: Journal Article
• Authors: Ito, Tomohiko; Hashimoto, Yoshiya; Baba, Shunsuke; Iseki, Tomio; Morita, Shosuke
• Is Part Of: Implant dentistry. Volume 24:Issue 2(2015:Apr.)
• Publication Date: 2015-04
• Subjects: bone regeneration -- synthesized collagen model polypeptides -- porous alpha-tricalcium phosphate; Dental implants -- Periodicals; 617.69305
• DOI: 10.1097/ID.0000000000000210
• Languages: English
• ISSNs: 1056-6163

Abstract

Abstract : Introduction: We evaluated the effects of synthesized collagen model polypeptides consisting of a proline-hydroxyproline-glycine (poly(PHG)) sequence combined with porous alpha-tricalcium phosphate (α-TCP) particles on bone formation in a canine tibia defect model. Materials and Methods: The porous α-TCP particles were mixed with a poly(PHG) solution, and the obtained sponge was then cross-linked and characterized by x-ray diffraction and scanning electron microscopy. Tibia defects were analyzed in 12 healthy beagles using microcomputed tomography and histological evaluation. Results: At 2 and 4 weeks, the volume density of new bone was higher in the poly(PHG)/α-TCP group than in poly(PHG) alone group ( P < 0.05); however, there was no difference at 8 weeks ( P > 0.05). Histological evaluation at 4 weeks after implantation revealed that the poly(PHG) had degraded, and newly formed bone was present on the surface of the α-TCP particles. At 8 weeks, continuous cortical bone formation with a Haversian structure covered the top of the bone defects in both groups. Conclusion: This study demonstrates that the composite created using porous α-TCP particles and poly(PHG) is sufficiently adaptable for treating bone defects.