Selective Y Centromere Inactivation Triggers Chromosome Shattering in Micronuclei and Repair by Non-homologous End Joining. Issue 5 (May 2017)

• Record Type: Journal Article
• Authors: Ly, Peter; Teitz, Levi S.; Kim, Dong H.; Shoshani, Ofer; Skaletsky, Helen; Fachinetti, Daniele; Page, David C.; Cleveland, Don W.
• Is Part Of: Obstetrical & gynecological survey. Volume 72:Issue 5(2017)
• Publication Date: 2017-05
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Surgery -- Periodicals; 618
• DOI: 10.1097/OGX.0000000000000440
• Languages: English
• ISSNs: 0029-7828

Abstract

Abstract : (Abstracted from Nat Cell Biol 2017;19:68–75) Evidence from plant models, human-cell models, and yeast genetics has suggested that complex and localized rearrangements termed chromothripsis can be triggered by chromosome missegregation into nuclear compartments called micronuclei . Chromothripsis is likely to arise through chromosome breakage and inaccurate reassembly.