Susceptibility of Trichophyton mentagrophytes to Visible Light Wavelengths. (May 2017)

• Record Type: Journal Article
• Authors: Guffey, J. Stephen; Payne, William; Buchanan, Ben; Daugherty, Jessie; Meurer;, Logan; Hensley, Patricia
• Is Part Of: Advances in skin & wound care. Volume 30:Number 5(2017)
• Publication Date: 2017-05
• Subjects: blue light -- fungal infection -- growth inhibition -- Trichophyton mentagrophytes; Wounds and injuries -- Treatment -- Periodicals; Wound healing -- Periodicals; Skin -- Diseases -- Treatment -- Periodicals; Dermatology -- United States -- Periodicals; 617.106
• DOI: 10.1097/01.ASW.0000512271.19164.ef
• Languages: English
• ISSNs: 1527-7941

Abstract

ABSTRACT: OBJECTIVE: To determine whether a blue light (405 nm) could inhibit the growth of Trichophyton mentagrophytes without using a photosensitizing material as part of the treatment protocol. DESIGN: Basic physiologic randomized trial using laboratory specimens ( T mentagrophytes ). INTERVENTIONS/METHODS: Plated on a growth medium, T mentagrophytes were exposed to 3 to 5 administrations of blue light at 20 J/cm 2 over 28 hours. Following 7 days of incubation, colony-forming units were counted and compared with nonirradiated controls. RESULTS: The study found 3, 4, and 5 administrations of blue light produced significant inhibition of T mentagrophytes ( P < .05); 4 and 5 applications produced the greatest inhibition of growth (84.7% and 93.6% kill rates, respectively). CONCLUSIONS: The application of 405-nm light at a dose of 20 J/cm 2 is an effective in vitro inhibitor of T mentagrophytes . To give results similar to those seen when a photosensitizing material is included, 3 to 5 applications of this wavelength and dose condition delivered over 28 hours is likely needed.