Simulated games activity vs continuous running exercise: A novel comparison of the glycemic and metabolic responses in T1DM patients. Issue 2 (4th March 2014)

• Record Type: Journal Article
• Authors: Campbell, M. D.; West, D. J.; Bain, S. C.; Kingsley, M. I. C.; Foley, P.; Kilduff, L.; Turner, D.; Gray, B.; Stephens, J. W.; Bracken, R. M.
• Is Part Of: Scandinavian journal of medicine & science in sports. Volume 25:Issue 2(2015)
• Page Start: 216
• Page End: 222
• Publication Date: 2014-03-04
• Subjects: T1DM -- post‐exercise hypoglycemia -- intermittent running; Sports medicine -- Periodicals; Sports -- Physiological aspects -- Periodicals; Sports -- Periodicals; 617.1027
• DOI: 10.1111/sms.12192
• Languages: English
• ISSNs: 0905-7188

Abstract

Abstract : To compare the glycemic and metabolic responses to simulated intermittent games activity and continuous running exercise in type 1 diabetes. Nine patients (seven male, two female; 35 ± 4 years; HbA1c 8.1 ± 0.2%/65 ± 2 mmol/mol) treated on a basal‐bolus regimen completed two main trials, a continuous treadmill run (CON) or an intermittent running protocol (INT). Patients arrived to the laboratory fasted at ∼ 08:00 h, replicating their usual pre‐exercise meal and administering a 50% reduced dose of rapid‐acting insulin before exercising. Blood glucose (BG), K +, Na ++, pH, triglycerides, serum cortisol and NEFA were measured at baseline and for 60 min post‐exercise. Interstitial glucose was measured for a further 23 h under free‐living conditions. Following exercise, BG declined under both conditions but was less under INT (INT −1.1 ± 1.4 vs CON −5.3 ± 0.4 mmol/L, P = 0.037), meaning more patients experienced hypoglycemia (BG ≤ 3.5 mmol/L; CON n = 3 vs INT n = 2) but less hyperglycemia (BG ≥ 10.9 mmol/L; CON n = 0 vs INT n = 6) under CON. Blood lactate was significantly greater, and pH lower, with a temporal delay in K + under INT ( P < 0.05). No conditional differences were observed in other measures during this time, or in interstitial glucose concentrations during the remaining 23 h after exercise. Simulated games activity carries a lower risk of early, but not late‐onset hypoglycemia than continuous running exercise in type 1 diabetes.