Synthesis, physicochemical characteristics, and biocompatibility of self‐assemble polymers bearing guanine, cytosine, uracil, and thymine moieties. Issue 9 (7th February 2015)

• Record Type: Journal Article
• Authors: Kim, Jin Chul; Kim, Mihee; Jung, Jungwoon; Lee, Jinseok; Ree, Brian J.; Kim, Heesoo; Kim, Ik Jung; Kim, Jung Ran; Ree, Moonhor
• Is Part Of: Journal of polymer science. Volume 53:Issue 9(2015:May)
• Page Start: 1151
• Page End: 1160
• Publication Date: 2015-02-07
• Subjects: biocompatibility -- biomaterials -- biomimetic -- synthesis -- self‐assembly -- thin films; 547
• DOI: 10.1002/pola.27546
• Languages: English
• ISSNs: 0887-624X

Abstract

ABSTRACT: We synthesized chemically well‐defined brush (i.e., comb‐like) polymers bearing guanine, cytosine, uracil, or thymine moieties at the bristle ends. The polymers were stable up to 220 °C and were readily solution‐processable, yielding high‐quality films. Interestingly, the brush polymers favorably self‐assembled to form molecular multibilayer structures stabilized by hydrogen bonding interactions among the nucleobase moieties at the bristle ends, which provided nucleobase‐rich surfaces. The multibilayer‐structured polymer films showed high water affinity. They also displayed selective protein adsorption, suppressed bacterial adherence, facilitated cell adhesion, and exhibited good biocompatibility in mice. The brush polymer DNA‐mimicking comb‐like polymers are suitable as biomaterials and in protein separation applications. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem.2015, 53, 1151–1160 Abstract : Chemically well‐defined brush polymers bearing guanine, cytosine, uracil, or thymine moieties at the bristle ends were synthesized. These polymers were thermally stable, and readily solution‐processable, yielding high‐quality films. They favorably self‐assembled as molecular multibilayer structures, always providing nucleobase‐rich surfaces. The multibilayer‐structured polymer films showed water affinity and selective protein adsorption, suppressed bacterial adherence, facilitated cell adhesion, exhibited good biocompatibility in mice, and are suitable as biomaterials and in protein separation applications.