Factors influencing sleep time with oxygen saturation below 90% in sleep‐disordered breathing. (19th September 2014)

• Record Type: Journal Article
• Authors: Bostanci, Asli; Turhan, Murat; Bozkurt, Selen
• Is Part Of: Laryngoscope. Volume 125:Number 4(2015:Apr.)
• Page Start: 1008
• Page End: 1012
• Publication Date: 2014-09-19
• Subjects: Obstructive sleep apnea -- sleep time with oxygen saturation below 90% -- hypoxia; Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.24942
• Languages: English
• ISSNs: 0023-852X

Abstract

Abstract : Objectives/Hypothesis: To determine factors influencing sleep time with oxygen saturation below 90% (ST90 ) in a population referred to a tertiary sleep center for assessment of possible sleep‐disordered breathing (SDB). Study Design: Retrospective review of demographic and polysomnographic data of 731 consecutive patients with suspected SDB. Methods: Bivariate correlation analyses were performed, and Spearman rho coefficients were calculated. Variables with a marginal association with ST90 ( P < .05) in the bivariate analysis were included into the multiple regression analysis. Results: The distributions of SDB were as follows: normal/simple snoring, 18.2%; mild obstructive sleep apnea (OSA), 25.6%; moderate OSA, 17.4%; and severe OSA, 38.9%. The univariate analysis revealed a significant correlation between ST90 and age ( r = 0.204), body mass index (BMI) ( r = 0.440), arousal index ( r = 0.754), apnea‐hypopnea index (AHI) ( r = 0.761), mean oxygen saturation (SaO2 ) ( r = −0.506), and mean O2 desaturation ( r = 0.858) ( P < .001 for all parameters). In multiple regression analysis, age ( P < .001), BMI ( P = .040), male gender ( P = .001), AHI ( P < .001), mean SaO2 ( P < .001), and mean O2 desaturation ( P < .001) were found to be independent parameters influencing ST90 . Furthermore, these parameters explained a significant proportion of variance in ST90 ( R 2 = 0.794, F (6, 729) = 464.65, P < .001). Although there was a strong correlation between AHI and ST90 ( r = 0.76, P < .001), a large variation of ST90 values was observed, especially within the severe OSA group. Conclusions: The study results provide supporting evidence that patients with similar AHI may have quite different values of ST90, and thereby hypoxia. The stratification of patients with OSA according to AHI combined with ST90 may allow better identification of prognostic information. Level of Evidence: 4 Laryngoscope, 125:1008–1012, 2015