A General Direct Arylation of Polyfluoroarenes with Heteroaryl and Aryl Chlorides Catalyzed by Palladium Indolylphosphine Complexes. Issue 4 (10th March 2015)

• Record Type: Journal Article
• Authors: Yuen, On Ying; Charoensak, Mueangkaew; So, Chau Ming; Kuhakarn, Chutima; Kwong, Fuk Yee
• Is Part Of: Chemistry, an Asian journal. Volume 10:Issue 4(2015:Apr.)
• Page Start: 857
• Page End: 861
• Publication Date: 2015-03-10
• Subjects: aryl chlorides -- CH arylation -- palladium -- phosphine -- polyfluoroarenes; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201500048
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: The first general examples of direct coupling of heteroaryl chlorides, especially substituted 2‐pyridyl chlorides which were previously found to be problematic, with electron‐deficient polyfluoroarenes are reported. Pd(OAc)2 associated with 3‐(dicyclohexylphosphino)‐2‐phenylindoleL1 serves as the effective catalyst which allows the challenging direct coupling of heteroaryl chlorides and polyfluoroarenes. In addition to heterocycles, a wide range of non‐activated and activated aryl chlorides and alkenyl chlorides were also applicable under this catalyst system. A catalyst loading down to 1 mol % Pd can be achieved. Abstract : No problem at all : The first general examples of direct coupling of heteroaryl chlorides, especially substituted‐2‐pyridyl chlorides which were previously found to be problematic, with electron‐deficient polyfluoroarenes are reported.