Evaluation of human glioma using in-vivo proton magnetic resonance spectroscopy combined with expression of cyclooxygenase-2: a preliminary clinical trial. Issue 7 (3rd May 2017)

• Record Type: Journal Article
• Authors: Shi, Wenqi; Li, Fuyan; Li, Hongxia; Xu, Yanjie; Zeng, Qingshi
• Is Part Of: NeuroReport. Volume 28:Issue 7(2017)
• Publication Date: 2017-05-03
• Subjects: biomarker -- cyclooxygenase-2 -- glioma -- 1H-MRS -- in vivo -- prognosis -- radiation; Neurosciences -- Periodicals; Nervous system -- Periodicals; Neurophysiology -- Periodicals; Nervous System Diseases -- Periodicals; Nervous System Physiological Phenomena -- Periodicals; Neurosciences -- Periodicals; 616.805
• DOI: 10.1097/WNR.0000000000000771
• Languages: English
• ISSNs: 0959-4965

Abstract

Abstract : We sought to investigate the correlation between in-vivo proton magnetic resonance spectroscopy ( 1 H-MRS) and cyclooxygenase-2 (COX-2) expression in human glioma, and to advance their roles in diagnostic mapping and monitoring of glioma biological behavior. Thirty-nine patients with different grades of glioma (WHO classification I–IV) included in this study were scanned at 3.0 T MR before operation or biopsy puncture. Tumor morphology and 1 H-MRS metabolites ratio [choline (Cho)/creatine (Cr)] were evaluated independently by two experienced radiologists. Paraffin-embedded glioma specimens were detected for the COX-2 expression using immunohistochemistry. Parametric and nonparametric tests including correlation, logistic regression and receiver operating characteristic analysis were applied to assess the predicative roles and relation diagram of 1 H-MRS and COX-2. The COX-2 expression showed a significant difference between low and high grade gliomas ( P <0.01). Varying degrees of COX-2 expression have positive correlation with the Cho/Cr values in tumor zone ( r =0.49, P =0.013), and showed not significant correlation with sex, age, and tumor location. For patients with high grade gliomas after surgery and radiation, COX-2 was associated with shortened survival in univariate analysis ( P =0.025). The COX-2, Cho/Cr value and age were the significant prognostic indicators shown in multivariate survival analysis. The COX-2 and Cho/Cr value of 1 H-MRS have correlation, and are both positive indicators for overall survival of human high grade glioma, and could be combined as a joint role to provide more evidences to assess the biological behavior.