Dengue-associated hemophagocyticlymphohistiocytosis in an adult: A case report and literature review. Issue 8 (February 2017)

• Record Type: Journal Article
• Authors: Chung, Sang Mi; Song, Joon Young; Kim, Wonshik; Choi, Min Joo; Jeon, Ji Ho; Kang, Seonghui; Jung, Eunju; Noh, Ji Yun; Cheong, Hee Jin; Kim, Woo Joo
• Other Names: Rosenthal. Ken S. section editor.
• Is Part Of: Medicine. Volume 96:Issue 8(2017)
• Publication Date: 2017-02
• Subjects: corticosteroid -- dengue hemorrhagic fever -- severe dengue -- hemophagocyticlymphohistiocytosis; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000006159
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. Case summary: A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH. After the initiation of corticosteroid therapy, the patient recovered and laboratory findings were normalized. Conclusion: It would be important to differentially diagnose dengue-associated HLH from severe DHF. Early recognition and initiation of steroid treatment would be crucial for the successful treatment of dengue fever complicated by HLH.