Direct and Efficient (Carbonyl)cobalt‐Mediated Aryl Acetylation Using [11C]Methyl Iodide. Issue 16 (23rd May 2016)

• Record Type: Journal Article
• Authors: Dahl, Kenneth; Schou, Magnus; Halldin, Christer
• Is Part Of: European journal of organic chemistry. Issue 16(2016)
• Page Start: 2775
• Page End: 2777
• Publication Date: 2016-05-23
• Subjects: Radiochemistry -- Carbon‐11 -- Positron emission tomography -- Carbonylation -- Cobalt -- Carbonyl ligands; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201600085
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A new strategy is reported that allows direct access to 11 C‐labelled aryl methyl ketones by a fast and efficient (carbonyl)cobalt‐mediated protocol employing [ 11 C]methyl iodide as the labelling agent. The method uses Co2 CO8 as combined aryl halide activator and carbon monoxide source for the carbonylation reaction. The suitability of the methodology was demonstrated by the 11 C‐labelling of a set of functionalised arenes and heteroarenes with radiochemical conversions (RCC) ranging from 22 % to 63 %. Abstract : A new strategy is reported that allows direct access to 11 C‐labelled aryl methyl ketones via a fast and efficient cobalt carbonyl‐mediated protocol using (hetero)aryl halides as substrate. RCC = radiochemical conversion.