Serum uromodulin is associated with impaired glucose metabolism. Issue 5 (February 2017)

• Record Type: Journal Article
• Authors: Leiherer, Andreas; Muendlein, Axel; Saely, Christoph H.; Kinz, Elena; Brandtner, Eva M.; Fraunberger, Peter; Drexel, Heinz
• Other Names: Steubl. Dominik section editor.
• Is Part Of: Medicine. Volume 96:Issue 5(2017)
• Publication Date: 2017-02
• Subjects: coronary patients -- glucose metabolism -- kidney disease -- renal biomarker -- serum -- T2DM -- Tamm–Horsfall protein (THP) -- uromodulin; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000005798
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: Uromodulin is the most abundant urine protein under physiological conditions. It has recently been described as a serum and plasma marker for kidney disease. Whether uromodulin is associated with impaired glucose metabolism is unknown. We therefore measured serum uromodulin and glucose traits in a cohort of 529 consecutively recruited patients. Serum uromodulin was significantly and inversely correlated with fasting plasma glucose ( r = −0.161; P < 0.001), with plasma glucose 2 hours after an oral 75 g glucose challenge ( r = −0.158; P = 0.001), and with HbA1c ( r = −0.103; P = 0.018). A total of 146 (27.6%) of our patients had type 2 diabetes mellitus (T2DM). Analysis of covariance confirmed that T2DM was an independent determinant of serum uromodulin (F = 5.5, P = 0.020) after multivariate adjustment including hypertension and glomerular filtration rate. Prospectively, uromodulin was lowest in patients with T2DM at baseline, higher in initially nondiabetic subjects who developed diabetes during follow-up (FU) and highest among nondiabetic patients (147.7 ± 69.9 vs 164 ± 67 vs 179.9 ± 82.2 ng/mL, P trend < 0.001). Similar results were seen with respect to prediabetes (168.0 ± 81.2 vs 172.8 ± 66.3 vs 188.2 ± 74.0 ng/mL, P = 0.011). We conclude that serum uromodulin is significantly associated with impaired glucose metabolism and the development of prediabetes and diabetes.