Systemic immune-inflammation index (SII) is a useful prognostic indicator for patients with squamous cell carcinoma of the esophagus. Issue 4 (January 2017)

• Record Type: Journal Article
• Authors: Feng, Ji-Feng; Chen, Sheng; Yang, Xun
• Other Names: Liu. Yong section editor.
• Is Part Of: Medicine. Volume 96:Issue 4(2017)
• Publication Date: 2017-01
• Subjects: cancer-specific survival (CSS) -- esophageal squamous cell carcinoma (ESCC) -- neutrophil to lymphocyte ratio (NLR) -- platelet to lymphocyte ratio (PLR) -- prognosis; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000005886
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: The aim of the study was to determine the prognostic role of systemic immune-inflammation index (SII) in patients with esophageal squamous cell carcinoma (ESCC). A total of 298 ESCC patients were enrolled in the current retrospective study. The SII was calculated by the formula: neutrophil × platelet/lymphocyte. The optimal cut-off value was calculated by the Cutoff Finder. Univariate and multivariate analyses were evaluated for cancer-specific survival (CSS). Additional, we also established a nomogram model to predict the prognosis for patients with ESCC. The optimal cut-off value was 410 × 10 9 /L for SII. Patients with SII ⩽ 410 (×10 9 /L) had a significantly better 5-year CSS than patients with SII > 410 (×10 9 /L) (51.9% vs 24.0%, P < 0.001). Multivariate analyses revealed that SII was a significant independent predictive indicator ( P = 0.027). A nomogram could be more accuracy for CSS for patients with ESCC (c-index: 0.68). The SII is a useful independent prognostic indicator for patients with resectable ESCC.