SALTIRE–RAAVE: targeting calcific aortic valve disease LDL-density-radius theory. (April 2015)

• Record Type: Journal Article
• Authors: Rajamannan, Nalini M; Greve, Anders M; Moura, Luis M; Best, Patricia; Wachtell, Kristian
• Is Part Of: Expert review of cardiovascular therapy. Volume 13:Number 4(2015)
• Page Start: 355
• Page End: 367
• Publication Date: 2015-04
• Subjects: aortic valve stenosis -- atherosclerosis -- calcification -- clinical trials -- hemodynamics -- statins; Cardiovascular agents -- Research -- Periodicals; 616.12061
• DOI: 10.1586/14779072.2015.1025058
• Languages: English
• ISSNs: 1477-9072

Abstract

Abstract : SALTIRE and RAAVE were the first two studies to evaluate the use of statin therapy for impeding calcific aortic valve disease (CAVD). This review presents the findings of low-density lipoprotein (LDL)-density-radius theory as tested using the combined results from the SALTIRE and RAAVE studies. Patients who received statin therapy had a greater degree of LDL cholesterol lowering, seen as the % change in LDL (47 vs 2%, p = 0.012), which in itself was significantly associated with a lesser change in aortic valve area (AVA; p < 0.001 and R 2 = 0.27). The percent change in the AVA for the treated patients was 5% and 15% for the nontreated patients (p = 0.579 and R 2 = 0.03). In summary, these published findings suggest that when applying the LDL-density-radius theory, which combines the cellular biology and the hemodynamics as defined by the continuity equation for AVA, there may be a role for lipid-lowering therapy in contemporary patients with calcific aortic valve disease (CAVD).