Transcriptional control of yeast ribosome biogenesis: A multifaceted role for general regulatory factors. Issue 4 (8th August 2017)

• Record Type: Journal Article
• Authors: Bosio, Maria Cristina; Fermi, Beatrice; Dieci, Giorgio
• Is Part Of: Transcription. Volume 8:Issue 4(2017)
• Page Start: 254
• Page End: 260
• Publication Date: 2017-08-08
• Subjects: Abf1 -- histone acetylation -- Rap1 -- Reb1 -- Ribi genes -- Rpd3 histone deacetylase -- Tbf1; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2017.1317378
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: In Saccharomyces cerevisiae, a group of more than 200 co-regulated genes (Ribi genes) is involved in ribosome biogenesis. This regulon has recently been shown to rely on a small set of transcriptional regulators (mainly Abf1, but also Reb1, Tbf1 and Rap1) previously referred to as general regulatory factors (GRFs) because of their widespread binding and action at many promoters and other specialized genomic regions. Intriguingly, Abf1 binding to Ribi genes is differentially modulated in response to distinct nutrition signaling pathways. Such a dynamic promoter association has the potential to orchestrate both activation and repression of Ribi genes in synergy with neighboring regulatory sites and through the functional interplay of histone acetyltransferases and deacetylases.