Associations of nicotinamide N-methyltransferase gene single nucleotide polymorphisms with sport performance and relative maximal oxygen uptake. Issue 22 (17th November 2017)

• Record Type: Journal Article
• Authors: Li, Jiang-Hua; Chen, Wei; Zhu, Xiao-Juan; Lin, Ya-Jun; Qiu, Li-Qiang; Cai, Can-Xin; Wang, Ya-Hui; Xiong, Qun; Chen, Fei; Chen, Li-Hui
• Is Part Of: Journal of sports sciences. Volume 35:Issue 22(2017)
• Page Start: 2185
• Page End: 2190
• Publication Date: 2017-11-17
• Subjects: Sport performance -- gene polymorphisms -- maximal oxygen uptake -- nicotinamide N-methyltransferase -- genotypes; Sports -- Periodicals; Sports -- Physiological aspects -- Periodicals; Sports -- Psychological aspects -- Periodicals; 612.044
• DOI: 10.1080/02640414.2016.1261176
• Languages: English
• ISSNs: 0264-0414

Abstract

ABSTRACT: To observe the associations between single nucleotide polymorphisms (SNPs) of nicotinamide N -methyltransferase ( NNMT ) gene and sport performance and to analyse genotype associations of the associated SNPs with sport performance and relative maximal oxygen uptake ( ). Participants were selected from 685 Chinese Han male college students. The completion times of a 1000-m run and a 50-m run were used to reflect sport performance, respectively. Nineteen tagSNPs were genotyped with Polymerase chain reaction–ligase detection reaction. Relative was directly determined with a cardiopulmonary function analyser. A significant association was found between rs2256292 and 1000-m run performance, but no significant association was found between any tagSNPs and 50-m run performance. The genotype associations of rs2256292 with 1000-m run performance and with relative were both significant under the recessive model (CC vs. CG + GG). No tagSNP in NNMT is significantly associated with 50-m run performance but rs2256292 is significantly associated with 1000-m run performance. The genotype associations of rs2256292 with sport performance are significant under recessive model, and a higher relative may be the physiological reason for minor homozygote CC carriers being of the better 1000-m runners.