Does next-generation sequencing of cyst fluid improve management of pancreatic cystic neoplasms?. (3rd October 2017)

• Record Type: Journal Article
• Authors: Aronsson, Linus; Andersson, Roland; Swahn, Fredrik; Ansari, Daniel
• Is Part Of: Scandinavian journal of gastroenterology. Volume 52:Number 10(2017)
• Page Start: 1049
• Page End: 1051
• Publication Date: 2017-10-03
• Subjects: Pancreatic cystic lesions -- next-generation sequencing -- biomarker -- cyst fluid; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.1080/00365521.2017.1349175
• Languages: English
• ISSNs: 0036-5521

Abstract

Abstract: Pancreatic cystic lesions represent a heterogeneous group of diseases ranging from benign to malignant lesions. They are increasingly being detected due to the widespread use of cross-sectional imaging. Their management is a challenge because it is often not possible to reliably discriminate between malignant and nonmalignant lesions using current imaging technology. Next-generation sequencing (NGS) has the ability of both whole genome and targeted sequencing at a low cost and from a limited amount of DNA. NGS of cyst fluid aspired by endoscopic ultrasonography-guided fine-needle aspiration provides a valuable tool in biomarker research and may in the future help improve diagnosis and management of pancreatic cystic lesions.