Pyromellitimide benzoyl thiourea cross-linked carboxymethyl chitosan hydrogels as antimicrobial agents. Issue 17 (22nd November 2017)

• Record Type: Journal Article
• Authors: Mohamed, Nadia A.; Abd El-Ghany, Nahed A.
• Is Part Of: International journal of polymeric materials. Volume 66:Issue 17(2017)
• Page Start: 861
• Page End: 870
• Publication Date: 2017-11-22
• Subjects: Antimicrobial activity -- carboxymethyl chitosan -- characterization -- hydrogels -- pyromellitimide benzoyl diisothiocyanate cross-linker -- synthesis; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2017.1280794
• Languages: English
• ISSNs: 0091-4037

Abstract

ABSTRACT: A series of novel hydrogels based on carboxymethyl chitosan (CMCS) has been synthesized by a cross-linking reaction between CMCS and various amounts of N, N ′-bis [4-(isothiocyanate carbonyl)phenyl] pyromellitimide as a cross-linker to produce pyromellitimide benzoyl thiourea–CMCS hydrogels designated as PIBTU–CMCS (1–4). Hydrogel structures were identified by elemental analyses and FTIR and 1 H-NMR spectroscopy. The prepared hydrogels were characterized for their properties to understand the influence exerted by controlled structural variations in these hydrogels. All the hydrogels showed a greater antibacterial activity on Gram-positive than Gram-negative bacteria. They also exhibited higher antifungal activities. Their antimicrobial activity improved by increasing their cross-linking degree. GRAPHICAL ABSTRACT: