Synthesis of lamivudine (3TC) and its derivatives. (2nd September 2017)

• Record Type: Journal Article
• Authors: Akhtar, Rabia; Yousaf, Muhammad; Zahoor, Ameer Fawad; Naqvi, Syed Ali Raza; Abbas, Najum
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 192:Number 9(2017)
• Page Start: 989
• Page End: 1001
• Publication Date: 2017-09-02
• Subjects: Lamivudine (3TC) -- HIV infection -- hepatitis B -- drug discovery; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2017.1321648
• Languages: English
• ISSNs: 1042-6507

Abstract

GRAPHICAL ABSTRACT: ABSTRACT: Lamivudine (3TC; 2, 3-dideoxy-3-thiacytidine) is a reverse transcriptase inhibitor and used for the treatment of human immunodeficiency virus-1 (HIV-1) and hepatitis B virus (HBV) infection. Because of its potent antiviral activity, chemists investigated a lot of methods for the synthesis of lamivudine and its derivatives. In this review, different strategies adopted by synthetic/medicinal chemists towards the synthesis of lamivudine and its derivatives have been summarized.