Simple and economic elaboration of high purity CaCO3 particles for bone graft applications using a spray pyrolysis technique. Issue 33 (8th August 2017)

• Record Type: Journal Article
• Authors: Neumeyer, David; Venturini, Chiara; Ratel-Ramond, Nicolas; Verelst, Marc; Gourdon, Andre
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 33(2017)
• Page Start: 6897
• Page End: 6907
• Publication Date: 2017-08-08
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb00586e
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : CaCO3 particles obtained using spray pyrolysis possess all the requirements to constitute promising multi-purpose materials for bone graft applications. Abstract : Materials for bone grafting are a major health stake today. The existing synthetic materials only partially answer to the requirements for such uses and do not provide a real alternative solution to the classical way consisting of the reuse of natural osseous materials, known to create other problems. In the present work, we have prepared calcium carbonate powders using spray pyrolysis in the perspective to realize ideal and multi-purposed bricks to form bone graft materials, by bottom-up approaches, using classical techniques. The chemical reactions involved in the synthesis process consist in the thermal decomposition of calcium acetate. This precursor, a classical food additive, is known to be non toxic, easy to use and very cheap. Morphological and chemical characterization was conducted on the obtained materials. Depending on the pyrolysis temperature, we observed partial decomposition of calcium acetate or lime formation. An annealing step is consequently required to finalize the transformation. Finally, it appears that annealed products are pure calcite particles, having a spherical morphology and possessing a low dispersity in the micron size range. These particles exhibit an original internal structure, reinforcing and ensuring the preservation of their morphological characteristics during the sintering process. Furthermore, a porosity value compatible with drug carrier capabilities was measured on the obtained products. All these qualities allow us to consider a multi-purpose use of these particles in almost all types of bone graft materials.