Ag(i)-Catalyzed one-pot synthesis of 4-fluorobenzo[b][1, 6] naphthyridines and 4-fluoroisoquinolines via iminofluorination of alkynes with Selectfluor. Issue 9 (19th June 2017)

• Record Type: Journal Article
• Authors: Mishra, Kalpana; Singh, Jay Bahadur; Gupta, Tanu; Singh, Radhey M.
• Is Part Of: Organic chemistry frontiers. Volume 4:Issue 9(2017)
• Page Start: 1794
• Page End: 1798
• Publication Date: 2017-06-19
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c7qo00346c
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Ag(i )-Catalyzed one-pot synthesis of 4-fluorobenzo[ b ][1, 6]naphthyridines is described from o -alkynylquinolinyl aldehydes through imines. Abstract : Ag(i )-Catalyzed one-pot synthesis of 4-fluorobenzo[ b ][1, 6]naphthyridines is described from o -alkynylquinolinyl aldehydes through imines in good to excellent yields. Selectfluor is used as a fluorinating reagent and the reaction proceeded at room temperature in an open atmosphere. Reactions employed in this synthesis method are also applied for the synthesis of 8-fluoro-1, 6-naphthyridine, 7-fluoro-pyrazolo[4, 3- c ]pyridine and 4-fluoroisoquinoline derivatives. Standardized conditions were also applied on a gram scale reaction and gave a good yield of the product.