Mortality in incident dementia – results from the German Study on Aging, Cognition, and Dementia in Primary Care Patients. (5th June 2015)

• Record Type: Journal Article
• Authors: Roehr, S.; Luck, T.; Bickel, H.; Brettschneider, C.; Ernst, A.; Fuchs, A.; Heser, K.; König, H.‐H.; Jessen, F.; Lange, C.; Mösch, E.; Pentzek, M.; Steinmann, S.; Weyerer, S.; Werle, J.; Wiese, B.; Scherer, M.; Maier, W.; Riedel‐Heller, S. G.
• Other Names: Maier Wolfgang investigator.; Scherer Martin investigator.; Abholz Heinz‐Harald investigator.; Bachmann Cadja investigator.; Bickel Horst investigator.; Blank Wolfgang investigator.; van den Bussche Hendrik investigator.; Eifflaender‐Gorfer Sandra investigator.; Eisele Marion investigator.; Ernst Annette investigator.; Fuchs Angela investigator.; Heser Kathrin investigator.; Jessen Frank investigator.; Kaduszkiewicz Hanna investigator.; Kaufeler Teresa investigator.; Köhler Mirjam investigator.; König Hans‐Helmut investigator.; Koppara Alexander investigator.; Lange Carolin investigator.; Leicht Hanna investigator.; Luck Tobias investigator.; Luppa Melanie investigator.; Mayer Manfred investigator.; Mösch Edelgard investigator.; Olbrich Julia investigator.; Pentzek Michael investigator.; Prokein Jana investigator.; Schumacher Anna investigator.; Riedel‐Heller Steffi investigator.; Stein Janine investigator.; Steinmann Susanne investigator.; Tebarth Franziska investigator.; Wagner Michael investigator.; Weckbecker Klaus investigator.; Weeg Dagmar investigator.; Werle Jochen investigator.; Weyerer Siegfried investigator.; Wiese Birgitt investigator.; Wolfsgruber Steffen investigator.; Zimmermann Thomas investigator.;
• Is Part Of: Acta psychiatrica Scandinavica. Volume 132:Number 4(2015:Oct.)
• Page Start: 257
• Page End: 269
• Publication Date: 2015-06-05
• Subjects: dementia -- mortality -- prognosis -- risk factors -- subjective memory complaints; Psychiatry -- Periodicals; 616.89
• DOI: 10.1111/acps.12454
• Languages: English
• ISSNs: 0001-690X

Abstract

Abstract : Objective: Dementia is known to increase mortality, but the relative loss of life years and contributing factors are not well established. Thus, we aimed to investigate mortality in incident dementia from disease onset. Method: Data were derived from the prospective longitudinal German AgeCoDe study. We used proportional hazards models to assess the impact of sociodemographic and health characteristics on mortality after dementia onset, Kaplan–Meier method for median survival times. Results: Of 3214 subjects at risk, 523 (16.3%) developed incident dementia during a 9‐year follow‐up period. Median survival time after onset was 3.2 years (95% CI = 2.8–3.7) at a mean age of 85.0 (SD = 4.0) years (≥2.6 life years lost compared with the general German population). Survival was shorter in older age, males other dementias than Alzheimer's, and in the absence of subjective memory complaints (SMC). Conclusion: Our findings emphasize that dementia substantially shortens life expectancy. Future studies should further investigate the potential impact of SMC on mortality in dementia.