Synthesis and evaluation of hyaluronic acid hydrogels modified with various crosslinkers as biodegradable polymers. Issue 43 (11th July 2017)

• Record Type: Journal Article
• Authors: Obata, H.; Yamazaki, Y.; Matsunaga, T.; Sato, T.
• Is Part Of: Journal of applied polymer science. Volume 134:Issue 43(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-07-11
• Subjects: biocompatibility -- biomaterials -- drug delivery systems -- hydrophilic polymers -- polysaccharides; Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.45453
• Languages: English
• ISSNs: 0021-8995

Abstract

ABSTRACT: Hyaluronic acid (HA), a high‐molecular‐weight natural polysaccharide, is often used in medical devices for regenerative medicine as it can undergo biodegradation via enzymatic action in the human body. HA exhibits both viscoelasticity and high biocompatibility and has therefore been used for ocular surgery. In particular, HA‐based hydrogels have been utilized as cell scaffold materials and devices in ophthalmological treatments. In this study, four hydrogels have been synthesized from HA derivatives with methacrylate groups and modified with crosslinkers such as adipic acid dihydrazide, divinyl sulfone, and dithiothreitol. Each of the synthesized hydrogels exhibits high transparency and strength as well as biodegradability in vitro . Hence, these HA‐based hydrogels demonstrate potential for applications as drug delivery systems and implants. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2017, 134, 45453. Abstract :