Lower sensitivity of serum (1, 3)-β-d-glucan for the diagnosis of candidaemia due to Candida parapsilosis. (July 2016)

• Record Type: Journal Article
• Authors: Mikulska, M.; Giacobbe, D.R.; Furfaro, E.; Mesini, A.; Marchese, A.; Del Bono, V.; Viscoli, C.
• Is Part Of: Clinical microbiology and infection. Volume 22:Number 7(2016)
• Page Start: 646.e5
• Page End: 646.e8
• Publication Date: 2016-07
• Subjects: Candida parapsilosis -- Fungitell -- Glucan -- Non-albicans -- Performance; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2016.05.020
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: The aim of this study was to evaluate the sensitivity and the levels of 1, 3-β-d -glucan (BDG) among patients with candidaemia due to different Candida species. Retrospective study of all patients who had a single-species candidaemia and BDG testing performed within 48 h from the onset of candidaemia during 2009–2015 was performed. Factors influencing the sensitivity of BDG, including the presence of a central venous catheter, antifungal therapy and Candida species, were analysed in univariate and multivariate models. In all, 107 patients with the following Candida distribution were included: 46 (43%) Candida albicans, 37 (35%) Candida parapsilosis, and 24 (22%) other species. BDG sensitivity and levels were the highest in C. albicans candidaemia and lowest for C. parapsilosis (respectively, 72% and 410 pg/mL for C. albicans, 41% and 39 pg/mL for C. parapsilosis, and 63% and 149 pg/mL for other species; p 0.015 and p 0.003). In multivariate analysis, Candida species ( parapsilosis versus others) was the only factor influencing the sensitivity of BDG (OR 0.3, 95% CI 0.1–0.7, p 0.006). The sensitivity of BDG in candidaemia seems highly dependent on the fungal species, with the lowest being for C. parapsilosis .