Age-related changes in rat prostate tissue; perspective of protein oxidation. (28th August 2014)

• Record Type: Journal Article
• Authors: Uzun, Duygu; Yanar, Karolin; Atukeren, Pınar; Cebe, Tamer; Mengi, Murat; Ozan, Tuna; Kunbaz, Ahmad; Kuruç, Aylin Irmak; Çakatay, Ufuk; Aydın, Seval
• Is Part Of: Aging male. Volume 18:Number 1(2015:Mar.)
• Page Start: 54
• Page End: 59
• Publication Date: 2014-08-28
• Subjects: Aging -- antioxidant capacity -- lipid peroxidation -- prostate -- protein oxidation; Aging -- Periodicals; Men -- Periodicals; Gerontology -- Periodicals; Men -- Health and hygiene -- Periodicals; Aging -- periodicals; Geriatric -- periodicals; Men -- periodicals; Aged -- periodicals; Aged, 80 and over -- periodicals; 612.67
• DOI: 10.3109/13685538.2014.951921
• Languages: English
• ISSNs: 1368-5538

Abstract

Abstract: Background : Increased systemic oxidative stress is considered as an important risk factor for prostate cancer occurrence; however, the relationship between impaired redox homeostasis of prostate tissue and aging remains unclear. Objective : In our study, we hypothesized that age-related deterioration of redox homeostasis in prostate tissue may be considered as a predisposing factor for prostate cancer occurrence. Methods : Sprague–Dawley rats were divided into two groups as young control (5 months) and naturally aged (24 months). We investigated the levels of oxidant and antioxidant parameters in prostate tissue. Results : Advanced oxidation protein products, protein carbonyl, non-protein thiol and lipid hydroperoxides levels of aged rats were significantly higher than in the young control rats ( p < 0.01, p < 0.05, p < 0.001, p < 0.05, respectively). Additionally, antioxidant activity of Cu-Zn-superoxide dismutase in elderly group was significantly lower than young controls ( p < 0.05). Conclusions : We suggest that increased non-protein thiol levels found in aged rats may prevent further dissemination of oxidative protein damage. We also propose that the increased levels of oxidative protein damage markers and decreased Cu-Zn superoxide dismutase activity in aged prostate may be considered as a predisposing factor for prostate cancer. Further studies are warranted to clarify all these oxidative changes as initiation factors for prostate cancer in the association of aging with prostate cancer.