Exploring the gem-dimethyl effect in the formation of imine-based macrocycles and cages. (3rd August 2017)

• Record Type: Journal Article
• Authors: Madhu, Suresh; Rashmi, E. V.; Gonnade, Rajesh G.; Sanjayan, Gangadhar J.
• Is Part Of: New journal of chemistry. Volume 41:Number 17(2017)
• Page Start: 8721
• Page End: 8724
• Publication Date: 2017-08-03
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj02069d
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A series of imine-based macrocycles and cages has been synthesized using the gem -dimethyl effect as a platform. Following this strategy, imine-based macrocyclization could be performed even at higher concentration. Abstract : Using the gem -dimethyl effect as a platform, a variety of organic [2+2] macrocycles and [2+3] cofacial cages was obtained in high yields. Imine-based macrocyclization could be performed even at high concentrations (0.5 to 1.0 M), via instant mixing of aldehydes and amines.