Fluorinated near-infrared fluorescent probes for specific detection of Hg2+ in an aqueous medium and mitochondria of living cells. (26th July 2017)

• Record Type: Journal Article
• Authors: Long, Lei; Tan, Xu; Luo, Shenglin; Shi, Chunmeng
• Is Part Of: New journal of chemistry. Volume 41:Number 17(2017)
• Page Start: 8899
• Page End: 8904
• Publication Date: 2017-07-26
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj01327b
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A near-infrared fluorescent probe (IR-DFT) could be used for specifically and sensitively detecting Hg 2+ in mitochondria of living cells. Abstract : Mitochondria are one of the major targets for localization of mercury ions, where serious mercury-induced toxicity has been well documented. Here, we design two heptamethine cyanine dyes coupled with thymines on the N -alkyl chains, which can specifically chelate with Hg 2+ by forming a T–Hg–T complex to sensitively detect Hg 2+ in both aqueous solution and the mitochondria of living cells. Further studies revealed that the introduction of fluorine atoms on thymines would significantly enhance the binding ability of T–Hg–T, providing clues to develop more specific and sensitive Hg 2+ sensors.