Formulation approaches to improving the delivery of an antiviral drug with activity against seasonal flu. (8th November 2013)

• Record Type: Journal Article
• Authors: Sammeta, Srinivasa M.; Wang, Li; Mutyam, Shravan K.; O'Loughlin, Kathleen; Green, Carol E.; Werner, Milton H.; Kelly, Terence; Shankar, Gita N.
• Is Part Of: Pharmaceutical development and technology. Volume 20:Number 2(2015)
• Page Start: 169
• Page End: 175
• Publication Date: 2013-11-08
• Subjects: Bioavailability -- co-solvents -- cyclodextrins -- solubility -- Ussing chambers; Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.3109/10837450.2013.852574
• Languages: English
• ISSNs: 1083-7450

Abstract

Abstract: The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches. Different combinations of co-solvents, which were selected on the basis of high-throughput solubility screening, were subjected to in vitro intestinal drug permeability studies conducted with Ussing chambers. Vitamin E tocopherol polyethylene glycol succinate and propylene glycol based co-solvent formulations provided the maximum permeability coefficient for the drug. Inclusion complexes of the drug were prepared using hydroxypropyl-β-cyclodextrin and sulphobutylether cyclodextrins. Pharmacokinetic studies were carried out in male Sprague–Dawley rats for the selected formulations. The relative bioavailabilities of the drug with the co-solvent- and cyclodextrin-based formulations were found to be similar.