Protective effect of baicalein on renal ischemia/reperfusion injury in the rat. (18th December 2014)

• Record Type: Journal Article
• Authors: Wu, Kefei; Li, Hongyan; Tian, Jianwei; Lei, Wenjing
• Is Part Of: Renal failure. Volume 37:Number 2(2015)
• Page Start: 285
• Page End: 291
• Publication Date: 2014-12-18
• Subjects: Baicalein -- inflammatory effects -- ischemia–reperfusion injury -- kidney injury -- oxidative stress; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2014.991999
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: Objective : To investigate the protective effect and the mechanism of baicalein (Bai) in rats with renal ischemia–reperfusion injury (RIRI). Methods : Twenty-four male Sprague–Dawley rats were divided into three groups: sham, IR, and IR + Bai. Bai was administered by tail vein injection (30 mg/kg) 30 min before reperfusion in the IR + Bai group. The IR group and sham group received saline vehicle via the intravenous route. Results : Rats that underwent RIRI exhibited renal functional impairment, histological changes, significantly increased advanced oxidation protein product (AOPP) and malondialdehyde (MDA) levels ( p < 0.01), and ICAM-1 and MCP-1 protein and mRNA expression were significantly upregulated ( p < 0.01). Administration of Bai reduced AOPP and MDA levels, significantly inhibited expression of inflammatory factors ( p < 0.05), and markedly improved renal function. Conclusion : Bai promotes the recovery of renal function in established acute RIRI, and alleviates kidney injury in a rat model.