Correlation between Interleukin-6 and Thrombin–Antithrombin III Complex Levels in Retinal Diseases. (2nd September 2017)

• Record Type: Journal Article
• Authors: Ehrlich, Rita; Zahavi, Alon; Axer-Siegel, Ruth; Budnik, Ivan; Dreznik, Ayelet; Dahbash, Mor; Nisgav, Yael; Megiddo, Elinor; Kenet, Gili; Weinberger, Dov; Livnat, Tami
• Is Part Of: Current eye research. Volume 42:Number 9(2017)
• Page Start: 1269
• Page End: 1272
• Publication Date: 2017-09-02
• Subjects: Blood–retinal barrier -- coagulation -- inflammation -- interleukin-6 -- thrombin–antithrombin III -- vitreoretinal pathology; Ophthalmology -- Periodicals; Eye -- Diseases -- Periodicals; Ophthalmology -- Periodicals; 573.88
• DOI: 10.1080/02713683.2017.1313432
• Languages: English
• ISSNs: 0271-3683

Abstract

ABSTRACT: Purpose : This study aims to evaluate and correlate the levels of interleukin-6 (IL-6) and thrombin–antithrombin III complex (TAT) in the vitreous of patients with different vitreoretinal pathologies. Methods : Vitreous samples were collected from 78 patients scheduled for pars plana vitrectomy at a tertiary medical center. Patients were divided by the underlying vitreoretinal pathophysiology, as follows: macular hole (MH)/epiretinal membrane (ERM) ( n = 26); rhegmatogenous retinal detachment (RRD) ( n = 32); and proliferative diabetic retinopathy (PDR) ( n = 20). Levels of IL-6 and TAT were measured by enzyme-linked immunosorbent assay and compared among the groups. Results : A significant difference was found in the vitreal IL-6 and TAT levels between the MH/ERM group and both the PDR and RRD groups ( P < 0.001 for all). Diabetes was associated with higher IL-6 levels in the RRD group. Different relationships between the IL-6 and TAT levels were revealed in patients with different ocular pathologies. Conclusion : Our results imply that variations in vitreal TAT level may be attributable not only to an inflammatory reaction or blood–retinal barrier breakdown, but also to intraocular tissue-dependent regulation of thrombin.