Coupling solid-phase microextractions and surface-enhanced Raman scattering: towards a point-of-need tool for hepatic cancer screening. Issue 32 (9th August 2017)

• Record Type: Journal Article
• Authors: Granger, Jennifer H.; Skuratovsky, Aleksander; Porter, Marc D.; Scaife, Courtney L.; Shea, Jill E.; Li, Qun; Wang, Sean
• Is Part Of: Analytical methods. Volume 9:Issue 32(2017)
• Page Start: 4641
• Page End: 4646
• Publication Date: 2017-08-09
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/c7ay01689a
• Languages: English
• ISSNs: 1759-9660

Abstract

Abstract : A method for rapid, highly portable immunoassays at low limits of detection has been developed by combining solid-phase microextraction membranes, gold nanoparticle labels, and surface-enhanced Raman scattering. Abstract : A method for performing rapid, highly portable immunoassays at low limits of detection (LoD) has been developed by combining solid-phase microextraction membranes, gold nanoparticle labels, and surface-enhanced Raman scattering. The capability of this methodology is demonstrated through measurements of alphafetoprotein, a marker used to screen individuals for hepatocellular carcinoma, directly from human serum at an estimated LoD of 3 pg mL −1 in ∼2 min.