Gas–Liquid Segmented Flow Microfluidics for Screening Copper/TEMPO‐Catalyzed Aerobic Oxidation of Primary Alcohols. Issue 4 (4th March 2015)

• Record Type: Journal Article
• Authors: Vanoye, Laurent; Pablos, Mertxe; de Bellefon, Claude; Favre‐Réguillon, Alain
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 4(2015)
• Page Start: 739
• Page End: 746
• Publication Date: 2015-03-04
• Subjects: aerobic oxidation -- alcohols -- copper -- flow chemistry -- 2, 2, 6, 6‐tetramethylpiperidine N‐oxyl (TEMPO); Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201400925
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Aerobic oxidation using a combination of copper salts and 2, 2, 6, 6‐tetramethylpiperidine N ‐oxyl (TEMPO) represent useful tools for organic synthesis and several closely related catalyst systems have been reported. To gain further insights, these catalytic systems were evaluated in a gas–liquid segmented flow device. The improvement of oxygen mass transfer has a significant influence on the turnover‐limiting step. Hence, an improved catalytic system using copper(II) as copper source was implemented in a microreactor for the safe and efficient oxidation of primary alcohol. Abstract :