Nickel‐Catalyzed Monoarylation of Ammonia1. (8th January 2015)

• Record Type: Journal Article
• Authors: Borzenko, Andrey; Rotta‐Loria, Nicolas L.; MacQueen, Preston M.; Lavoie, Christopher M.; McDonald, Robert; Stradiotto, Mark
• Is Part Of: Angewandte Chemie. Volume 127:Number 12(2015)
• Page Start: 3844
• Page End: 3848
• Publication Date: 2015-01-08
• Subjects: Aminierungen -- Ammoniak -- Arylierungen -- Kreuzkupplungen -- Nickel; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201410875
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Structurally diverse (hetero)aryl chloride, bromide, and tosylate electrophiles were employed in the Ni‐catalyzed monoarylation of ammonia, including chemoselective transformations. The employed JosiPhos/[Ni(cod)2 ] catalyst system enables the use of commercially available stock solutions of ammonia, or the use of ammonia gas in these reactions, thereby demonstrating the versatility and potential scalability of the reported protocol. Proof‐of‐principle experiments established that air‐stable [(JosiPhos)NiCl2 ] precatalysts can be employed successfully in such transformations.