Cancer Theranostics: Facile Preparation of Doxorubicin‐Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy (Adv. Healthcare Mater. 4/2015). Issue 4 (March 2015)

• Record Type: Journal Article
• Authors: Liu, Fuyao; He, Xiuxia; Lei, Zhen; Liu, Liang; Zhang, Junping; You, Hongpeng; Zhang, Huimao; Wang, Zhenxin
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 4(2015)
• Page Start: 479
• Page End: 479
• Publication Date: 2015-03
• Subjects: chemotherapy -- multimodality imaging -- photothermal therapy -- polydopamine -- upconversion nanoparticle; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201570021
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : On page 559, H. M. Zhang, Z. X. Wang, and colleagues directly coat polydopamine (PDA) on hydrophobic upconversion nanoparticle (UCNP) to form UCNP@PDA core–shell nanosphere via a microemulsion approach, further modified with polyethylene glycol (PEG). After loading with DOX, the UCNP@PDA‐PEG‐DOX can completely eradicate mouse‐bearing colorectal cancer without regrowth guided by multimodal imaging, demonstrating highly effective combined photothermal and chemotherapy of the nanocomposites.