Sucrose Non-Fermenting Related Kinase Expression in Ovarian Cancer and Correlation with Clinical Features. (9th August 2017)

• Record Type: Journal Article
• Authors: Hopp, Elizabeth E.; Cossette, Stephanie M.; Kumar, Suresh N.; Eastwood, Daniel; Ramchandran, Ramani; Bishop, Erin
• Is Part Of: Cancer investigation. Volume 35:Number 7(2017)
• Page Start: 456
• Page End: 462
• Publication Date: 2017-08-09
• Subjects: Ovarian cancer -- Cancer biomarkers -- Invasion & metastasis; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2017.1337781
• Languages: English
• ISSNs: 0735-7907

Abstract

ABSTRACT: Sucrose non-fermenting related kinase (SNRK) is a serine/threonine kinase known to regulate cellular metabolism and adipocyte inflammation. Since alterations in adipocyte metabolism play a role in ovarian cancer metastasis, we investigated the expression of SNRK in benign and malignant human ovarian tissue using immunohistochemistry and qPCR. The number of SNRK positive (+) nuclei is increased in malignant tissue compared to benign tissue (21.03% versus 14.90%, p < .0431). The most strongly stained malignant SNRK+ nuclei were stage 1 compared to stage 2–4 disease. Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis.