A poly(glycerol sebacate) based photo/thermo dual curable biodegradable and biocompatible polymer for biomedical applications. Issue 15 (13th October 2017)

• Record Type: Journal Article
• Authors: Wang, Min; Lei, Dong; Liu, Zenghe; Chen, Shuo; Sun, Lijie; Lv, Ziying; Huang, Peng; Jiang, Zhongxing; You, Zhengwei
• Is Part Of: Journal of biomaterials science. Volume 28:Issue 15(2017)
• Page Start: 1728
• Page End: 1739
• Publication Date: 2017-10-13
• Subjects: Biomedical engineering -- biomaterial -- poly (glycerol sebacate) -- 2-isocyanatoethyl methacrylate -- photo/thermo dual curable; Polymers -- Biocompatibility -- Periodicals; Biomedical materials -- Periodicals; 572.33
• DOI: 10.1080/09205063.2017.1348927
• Languages: English
• ISSNs: 0920-5063

Abstract

Abstract: Due to its biomimetic mechanical properties to soft tissues, excellent biocompatibility and biodegradability, poly (glycerol sebacate) (PGS) has emerged as a representative bioelastomer and been widely used in biomedical engineering. However, the typical curing of PGS needs high temperature (>120 °C), high vacuum (>1 Torr), and long duration (>12 h), which limit its further applications. Accordingly, we designed, synthesized and characterized a photo/thermo dual curable polymer based on PGS. Treatment of PGS with 2-isocyanatoethyl methacrylate without additional reagents readily produced a methacrylated PGS (PGS-IM). Photo-curing of PGS-IM for 10 min at room temperature using salt leaching method efficiently produced porous scaffolds with a thickness up to 1 mm. PGS-IM was adapt to thermo-curing as well. The combination of photo and thermo curing provided a further way to modulate the properties of resultant porous scaffolds. Interestingly, photo-cured scaffolds exhibited hierarchical porous structures carrying extensive micropores with a diameter from several to hundreds micrometers. All the scaffolds showed good elasticity and biodegradability. In addition, PGS-IM exhibited good compatibility with L929 fibroblast cells. We expect this new PGS based biomaterial will have a wide range of biomedical applications.