3-Nitro-2-pyridinesulfenyl-mediated solid-phase disulfide ligation in the synthesis of disulfide bond-containing cyclic peptides. Issue 11 (6th February 2015)

• Record Type: Journal Article
• Authors: Taguchi, Akihiro; Fukumoto, Kentarou; Asahina, Yuya; Kajiyama, Akihiro; Shimura, Shunsuke; Hamada, Keisuke; Takayama, Kentaro; Yakushiji, Fumika; Hojo, Hironobu; Hayashi, Yoshio
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 11(2015)
• Page Start: 3186
• Page End: 3189
• Publication Date: 2015-02-06
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob00030k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A new solid-phase disulfide ligation method is developed to prepare a disulfide peptide from two types of Cys-containing peptide fragments with minimum purification steps. Abstract : A new solid-phase disulfide ligation method is developed to prepare a disulfide peptide from two types of Cys-containing peptide fragments with minimum purification steps. In combination with the subsequent intramolecular amide bond formation, a cyclic nonapeptide, oxytocin, was efficiently synthesized as a fundamental model for more complex cyclic peptides.