Allogeneic stem cell transplant in patients with chronic lymphocytic leukemia with 17p deletion: consult-transplant versus consult- no-transplant analysis. Issue 3 (March 2015) - Poon, Michelle L.
Abstract: Allogeneic stem cell transplant (alloSCT) can overcome the adverse prognosis of chronic lymphocytic leukemia with 17p deletion (17p− CLL). However, its applicability remains unclear. Since 2007, our leukemia service has referred patients with 17p− CLL for alloSCT at presentation. In this study, the outcomes of these patients were reviewed retrospectively to determine whether they underwent alloSCT and why patients did not undergo alloSCT. Fifty-two patients with 17p− CLL who were referred to the transplant service from 2007 to 2010 were identified. Of these patients, 32 (62%) did not undergo alloSCT, mainly because of treatment- or disease-related complications ( n = 15). The 2-year post-referral overall survival rates of the alloSCT and non-SCT groups were 64% and 25%, respectively ( p = 0.001). These findings suggest that while alloSCT is an effective therapy in patients with 17p− CLL, pre-SCT complications may preclude a significant proportion of patients from undergoing the procedure.