Concise Review: The Role of Hematopoietic Stem Cell Transplantation in the Treatment of Acute Myeloid Leukemia123. (24th July 2012)

• Record Type: Journal Article
• Authors: Hamilton, Betty K.; Copelan, Edward A.
• Is Part Of: Stem cells. Volume 30:Number 8(2012)
• Page Start: 1581
• Page End: 1586
• Publication Date: 2012-07-24
• Subjects: Acute myelogenous leukemia -- Hematopoietic stem cell transplantation -- Adult hematopoietic stem cells -- Leukemia; Cloning -- Periodicals; Clone cells -- Periodicals; Stem cells -- Periodicals; Cell Differentiation -- Periodicals; Cell Division -- Periodicals; Clone Cells -- Periodicals; Hematopoietic Stem Cells -- Periodicals; Stem Cells -- Periodicals; 571.84
• DOI: 10.1002/stem.1140
• Languages: English
• ISSNs: 1066-5099

Abstract

Abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative option for patients with acute myeloid leukemia (AML). Our understanding of the biology of leukemic stem cells has continued to improve over the last decade and risk stratification using cytogenetics and molecular markers have improved our ability to select patients who would benefit from allogeneic transplantation. Results of HSCT have also improved substantitally, extending the potential application of allogeneic transplant to more patients. This review discusses the theoretical aspects of transplant, analyzes clinical results, and provides recommendations for the use of HSCT in AML. Further study of the biology of leukemic stem cells and the role for HSCT is necessary to optimize outcomes in AML patients. STEM CELLS 2012;30:1581–1586