Concise Review: Immune Recognition of Induced Pluripotent Stem Cells123. (9th April 2012)

• Record Type: Journal Article
• Authors: Boyd, Ashleigh S.; Rodrigues, Neil P.; Lui, Kathy O.; Fu, Xuemei; Xu, Yang
• Is Part Of: Stem cells. Volume 30:Number 5(2012)
• Page Start: 797
• Page End: 803
• Publication Date: 2012-04-09
• Subjects: Stem cells -- Embryonic stem cells -- Induced pluripotent stem cells -- Cell replacement therapy -- Immunogenicity -- Transplantation -- Tolerance -- Rejection -- Regenerative medicine; Cloning -- Periodicals; Clone cells -- Periodicals; Stem cells -- Periodicals; Cell Differentiation -- Periodicals; Cell Division -- Periodicals; Clone Cells -- Periodicals; Hematopoietic Stem Cells -- Periodicals; Stem Cells -- Periodicals; 571.84
• DOI: 10.1002/stem.1066
• Languages: English
• ISSNs: 1066-5099

Abstract

Abstract: Autologous‐induced pluripotent stem cells (iPSCs) may eventually be used in cell replacement therapies to treat a wide range of diseases and have been touted as a solution to the vexing problem of immune rejection in this context. Emerging evidence suggests, however, that ostensibly histocompatible iPSCs may be rejected following transplantation. Here, we review the mechanisms that contribute to immunogenicity in iPSCs and forward approaches to permit their acceptance in potential cell replacement therapies. STEM CELLS 2012;30:797–803